The Pelger-Huët Anomaly and Megaloblastic Anemia

The Pelger-huuet Anomaly and Megaloblastic Anemia.

By S. ARDEMAN, I. CIIANARIN AND A. \V. FRANKLAND T HE Pelger-Huet anomaly of Ieukocytcs is characterized by the ence of tii oval, indented or bibbed ( “pincc-nez” ) nucleus in the neutrophil polymorphonuclear leukocytes which replaces the normal nuclear segmentation of these cells ( Pelger’ ) . It is inherited as an autosomal dominant characteristic ( Hu#{235}t2 ) , the incidence being 1 in 600...

Understanding and recognizing the Pelger-Huët anomaly.

The Pelger-Huët anomaly (PHA) is a recognized morphologic variant affecting all granulocytes but is most evident in polymorphonuclear neutrophils (PMNs). PHA is caused by a decreased amount of the lamin B receptor (LBR). Recognition of PHA morphologic features serves as a marker for mutations in the LBR gene. This review summarizes the history of PHA and the current knowledge of the functions o...

The Pelger-Huët familial anomaly of leukocytes.

Homozygous form of the Pelger-Huët anomaly.

Pseudo-Pelger-Huët anomaly induced by medications: a clinicopathologic study in comparison with myelodysplastic syndrome-related pseudo-Pelger-Huët anomaly.

Pseudo-Pelger-Huët anomaly (PPHA) has been documented in association with transplant medications and other drugs. This iatrogenic neutrophilic dysplasia is reversible with cessation or adjustment of medications but is frequently confused with myelodysplastic syndrome (MDS) based on the conventional concept that PPHA is a marker for dysplasia. We investigated the clinicopathologic features in ia...